Prayer is not the thing you do when everything else has failed. It is the thing you do so you can face everything else.
Philippians 4:6
"Do not be anxious about anything, but in everything by prayer and supplication with thanksgiving let your requests be made known to God. And the peace of God, which surpasses all understanding, will guard your hearts and your minds in Christ Jesus."
Which part of this passage speaks most directly to where you are with prayer right now?